Otis is a town located within the central portion of Berkshire County, Massachusetts, in a strictly rural region primarily along Routes 8 and 23. Route 8 is north-south, retaining the number 8 into both Connecticut to the south and Vermont to the north, while Route 23 is east-west for the region. As with surrounding communities such as Tolland in Hampden County to the southeast and Sandisfield (also Berkshire County) to the southwest, the Town of Otis also serves as the namesake for an associated state forest unit within the Commonwealth (and the same is also true for numerous other communities, particularly in Western Mass). Overall, however, the Town of Otis is located nearly halfway from the Town of Great Barrington to the City of Springfield in Hampden County, toward the southeast of Berkshire County relative to most other communities located within.
